The Effects of Sevoflurane on Isolated Gravid Human Myometrium
- 1 October 2002
- journal article
- research article
- Published by SAGE Publications in Anaesthesia and Intensive Care
- Vol. 30 (5), 591-596
- https://doi.org/10.1177/0310057x0203000508
Abstract
The volatile anaesthetic agents are known to influence uterine muscle tone. All of the agents studied to date have been found to produce uterine relaxation. This property has been used to produce therapeutic uterine relaxation for difficult obstetric deliveries and the Ex Utero Intrapartum Treatment (EXIT) procedure. This study describes the effects of sevoflurane on isolated human myometrium at concentrations of 0.1, 0.25, 0.5, 0.75, 1.0, 1.5, 2.5 and 3.5 MAC. Sevoflurane produces dose-dependent depression of uterine muscle contractility with an ED 50 of 0.94 MAC. Frequency of contraction was increased at concentrations of 2.5 MAC and greater. At concentrations of 3.5 MAC and above, uterine activity was virtually abolished.Keywords
This publication has 25 references indexed in Scilit:
- Clinical Pharmacokinetics of SevofluraneClinical Pharmacokinetics, 1999
- Nitroglycerin to Facilitate Fetal Extraction During Cesarean DeliveryObstetrics & Gynecology, 1998
- Intravenous nitroglycerin for uterine relaxation of an inverted uterusAmerican Journal of Obstetrics and Gynecology, 1992
- Antepartum uterine relaxation with nitroglycerin at Caesarean deliveryCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 1992
- Clinical Comparison of Sevoflurane and Isoflurane in Healthy PatientsAnesthesia & Analgesia, 1992
- L'inversion utérine : urgence anesthésiologiqueAnnales Françaises dʼAnesthésie et de Réanimation, 1991
- Intravenous Nitroglycerin for Uterine Relaxation in the Postpartum Patient with Retained PlacentaAnesthesiology, 1989
- MAC of sevoflurane in humans and the New Zealand white rabbitCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 1988
- General Anesthesia in Cesarean SectionObstetrical & Gynecological Survey, 1984
- Enflurane, Isoflurane, and Halothane and Isolated Human Uterine MuscleAnesthesiology, 1977