The Short-Term and Long-Term Effects of Radical Prostatectomy on Lower Urinary Tract Symptoms
- 31 December 2007
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 178 (6), 2397-2401
- https://doi.org/10.1016/j.juro.2007.08.004
Abstract
Purpose: We determined the long-term effect of radical prostatectomy on lower urinary tract symptoms. Materials and Methods: Between October 1, 2000 and January 30, 2003, 587 men underwent open radical retropubic prostatectomy. Of these men 453 completed the American Urological Association symptom index at baseline, and 12 and 48 months. Mean changes in American Urological Association total, voiding and storage symptom scores were ascertained between baseline and 12 months (short term), baseline and 48 months (long term), and between 12 and 48 months (natural history of lower urinary tract symptoms without a prostate). Symptom scores were ascertained independently for men with baseline mild vs moderate/severe lower urinary tract symptoms. Results: Clinically and statistically significant short-term and long-term improvements were observed in mean American Urological Association total, storage and voiding symptom scores for men presenting with moderate/severe lower urinary tract symptoms. The previously reported progression of lower urinary tract symptoms in the general population of men older than 40 years was not observed in our patients with an absent prostate. Conclusions: The current study provides compelling evidence that radical prostatectomy prevents the progression of lower urinary tract symptoms in men with and without baseline clinically significant lower urinary tract symptoms. This beneficial effect of radical prostatectomy on the natural history of lower urinary tract symptoms should be considered when weighing the risks and benefit of the treatment option for localized prostate cancer.Keywords
This publication has 10 references indexed in Scilit:
- Natural history of voiding function after radical retropubic prostatectomyUrology, 2006
- The Impact of Open Radical Retropubic Prostatectomy on Continence and Lower Urinary Tract Symptoms: A Prospective Assessment Using Validated Self-Administered Outcome InstrumentsJournal of Urology, 2004
- The Natural History of Lower Urinary Tract Symptoms over Five YearsEuropean Urology, 2003
- Concomitant Longitudinal Changes in Frequency of and Bother From Lower Urinary Tract Symptoms in Community Dwelling MenJournal of Urology, 2002
- RADICAL RETROPUBLIC PROSTATECTOMYUrologic Clinics of North America, 2001
- RADICAL RETROPUBIC PROSTATECTOMY REDUCES SYMPTOM SCORES AND IMPROVES QUALITY OF LIFE IN MEN WITH MODERATE AND SEVERE LOWER URINARY TRACT SYMPTOMSJournal of Urology, 1999
- Benign Prostatic Hyperplasia Specific Health Status Measures in Clinical Research: How Much Change in the American Urological Association Symptom Index and the Benign Prostatic Hyperplasia Impact Index is Perceptible to Patients?Journal of Urology, 1995
- THE DEVELOPMENT AND CLINICAL UTILITY OF SYMPTOM SCORESUrologic Clinics of North America, 1995
- The prevalence of Prostatism: A Population-Based Survey of Urinary SymptomsJournal of Urology, 1993
- Etiology and disease process of benign prostatic hyperplasiaThe Prostate, 1989