Estimating Human Oral Fraction Dose Absorbed: A Correlation Using Rat Intestinal Membrane Permeability for Passive and Carrier-Mediated Compounds
- 1 January 1988
- journal article
- research article
- Published by Springer Science and Business Media LLC in Pharmaceutical Research
- Vol. 05 (10), 651-654
- https://doi.org/10.1023/a:1015927004752
Abstract
Based on a simple tube model for drug absorption, the key parameters controlling drug absorption are shown to be the dimensionless effective permeability, Peff*, and the Graetz number, Gz, when...This publication has 13 references indexed in Scilit:
- Oral absorption of 21-Corticosteroid Esters: A Function of Aqueous Stability and Intestinal Enzyme Activity and DistributionJournal of Pharmaceutical Sciences, 1986
- Application of a Radiotelemetric System to Evaluate the Performance of Enteric Coated and Plain Aspirin TabletsJournal of Pharmaceutical Sciences, 1986
- Mixing-Tank Model for Predicting Dissolution Rate Control of Oral AbsorptionJournal of Pharmaceutical Sciences, 1986
- Human intravenous pharmacokinetics and absolute oral bioavailability of cefatrizineAntimicrobial Agents and Chemotherapy, 1983
- The metabolism of [14C]cimetidine in manXenobiotica, 1982
- Pharmacokinetics of propranololJournal of Pharmacokinetics and Biopharmaceutics, 1981
- Analysis of models for determining intestinal wall permeabilitiesJournal of Pharmaceutical Sciences, 1980
- A convective mass transfer model for determining intestinal wall permeabilities: laminar flow in a circular tubeJournal of Theoretical Biology, 1980
- Dose‐dependent prednisolone kineticsCancer Cell, 1979
- PHARMACOKINETICS OF METHYLDOPA IN MAN1976