Prognostic Features in Tall Cell Papillary Carcinoma and Insular Thyroid Carcinoma
- 1 February 1997
- journal article
- research article
- Published by Wiley in The Laryngoscope
- Vol. 107 (2), 254-259
- https://doi.org/10.1097/00005537-199702000-00020
Abstract
Tall cell papillary carcinoma (TCPC) and insular carcinoma (IC) are variants of thyroid carcinoma that are considered to be more aggressive than well differentiated papillary or follicular carcinoma. To determine the clinical significance of these diagnoses, we evaluated 65 patients with these tumors. There were 30 TCPCs, 27 ICs, and 8 ICs or TCPCs with focal anaplastic carcinoma (FAC). Forty-two patients (27 TCPCs, 14 ICs, and 1 FAC) are alive and free of disease. Nine patients with IC are alive with distant metastases. Ten patients (2 TCPCs, 2 ICs, and 7 FACs) died of disease. Univariate analysis of disease-free interval determined that, as for all thyroid carcinomas, patient age, tumor size, extrathyroidal extension, and lymph node metastases were significant for prognosis. ICs did significantly worse than TCPCs. Focal anaplastic dedifferentiation predicted a worse prognosis. Multivariate analysis for disease-free interval showed age, number of lymph node metastases, and tumor type to be significant. Analysis of the same factors for prediction of mortality showed that TCPC and IC were not significantly different. These data suggest that TCPC is less aggressive than IC, which often results in disseminated disease. Focal AC predicts poor survival.Keywords
This publication has 21 references indexed in Scilit:
- Multivariate analysis of histopathological features as prognostic factors in patients with papillary thyroid carcinomaBritish Journal of Surgery, 1995
- Therapeutic implications of prognostic factors in differentiated carcinoma of the thyroid glandSeminars in Surgical Oncology, 1995
- Expression of Growth Factors and Growth Factor Receptors in Normal and Tumorous Human Thyroid TissuesThyroid®, 1995
- Tall cell papillary thyroid cancer: Incidence and prognosisThe American Journal of Surgery, 1994
- Stepwise Participation of p53 Gene Mutation During Dedifferentiation of Human Thyroid CarcinomasDiagnostic Molecular Pathology, 1994
- Prognostic factors and management considerations in patients with cervical metastases of thyroid cancerThe American Journal of Surgery, 1992
- Prognostic factors in differentiated carcinoma of the thyroid glandThe American Journal of Surgery, 1992
- Prognostic significance of cervical lymph node metastases in differentiated thyroid cancerThe American Journal of Surgery, 1992
- Prognostic Implications of the Tall Cell Variant of Papillary Thyroid CarcinomaThe American Journal of Surgical Pathology, 1988
- Papillary and follicular thyroid cancer: Prognostic factors in 1,578 patientsAmerican Journal Of Medicine, 1987