Combined use of ionic liquid and β-CD for enantioseparation of 12 pharmaceuticals using CE
- 10 January 2013
- journal article
- research article
- Published by Wiley in Journal of Separation Science
- Vol. 36 (3), 517-523
- https://doi.org/10.1002/jssc.201200824
Abstract
In this study, the enantioseparation of zopiclone, repaglinide, chlorphenamine maleate, brompheniramine maleate, dioxopromethazine hydrochloride, promethazine hydrochloride, liarozole, carvedilol, homatropine hydrobromide, homatropine methylbromide, venlafaxine, and sibutramine hydrochloride has been investigated using β-CD in combination with a chiral ionic liquid (IL), 1-ethyl-3-methylimidazolium-L-lactate. The influence of the type of IL and its concentration, BGE pH, and chain length of the IL cations on the resolution are discussed. Finally, the proposed method was successfully applied for the chiral impurity determination of eszopiclone in pharmaceutical tablets after validation with respect to accuracy and precision, linearity range, selectivity, repeatability, LOD and LOQ. It is assessed that the chiral impurity determination in the commercial tables is fewer than 0.1%.Keywords
Funding Information
- National Natural Science Foundation of China (30973675)
This publication has 25 references indexed in Scilit:
- Combined use of chiral ionic liquid and cyclodextrin for MEKC: Part I. Simultaneous enantioseparation of anionic profensElectrophoresis, 2009
- Interaction between β-cyclodextrin and ionic liquids in aqueous solutions investigated by a competitive method using a substituted 3H-indole probeJournal of Photochemistry and Photobiology A: Chemistry, 2008
- Application of 1-alkyl-3-methylimidazolium-based ionic liquids as background electrolyte in capillary zone electrophoresis for the simultaneous determination of five anthraquinones in RhubarbTalanta, 2007
- Dynamic coating of a capillary with room-temperature ionic liquids for the separation of amino acids and acid drugs by capillary electrophoresisJournal of Analytical Chemistry, 2006
- Synthesis, Characterization, and Application of Chiral Ionic Liquids and Their Polymers in Micellar Electrokinetic ChromatographyAnalytical Chemistry, 2006
- Enantioselective separation in capillary electrophoresis using a novel mono-6A-propylammonium-β-cyclodextrin as chiral selectorAnalytica Chimica Acta, 2006
- Sensitive chiral analysis by capillary electrophoresisElectrophoresis, 2006
- Polymeric alkenoxy amino acid surfactants: IV. Effects of hydrophobic chain length and degree of polymerization of molecular micelles on chiral separation of β-blockersElectrophoresis, 2005
- Ionic liquids as additives for separation of benzoic acid and chlorophenoxy acid herbicides by capillary electrophoresisAnalytica Chimica Acta, 2005
- Dynamically coating the capillary with 1-alkyl-3-methylimidazolium-based ionic liquids for separation of basic proteins by capillary electrophoresisAnalytica Chimica Acta, 2003