Does size matter in females? An overview of the impact of the high variation in the ovarian reserve on ovarian function and fertility, utility of anti-Müllerian hormone as a diagnostic marker for fertility and causes of variation in the ovarian reserve in cattle
- 1 January 2011
- journal article
- research article
- Published by CSIRO Publishing in Reproduction, Fertility and Development
- Vol. 23 (1), 1-14
- https://doi.org/10.1071/rd10226
Abstract
The mechanism whereby the inherently high variation in ovary size and the total number of high-quality oocytes in ovaries (ovarian reserve) impact on ovarian function and fertility, diagnostics to measure the size of the ovarian reserve and the factors that cause variation in the ovarian reserve are unknown. Our results show that cattle can be phenotyped reliably based on the number of antral follicles growing during follicular waves (antral follicle count, AFC). Young adult cattle with a consistently low v. a high AFC have smaller gonads, a markedly diminished ovarian reserve and many other phenotypic characteristics usually associated with ovarian aging and infertility. A powerful new approach based on a single measurement of serum concentration of anti-Müllerian hormone (AMH) is described to test the longstanding hypothesis that the size of the ovarian reserve is positively associated with fertility. Also, new evidence shows that maternal environment has a critical role in regulation of the high variation in the ovarian reserve and perhaps fertility in offspring. These results support the conclusion that the inherently high variation in the ovarian reserve, potentially caused by alterations in the maternal environment, has a negative impact on ovarian function that may result in suboptimal fertility in young adult cattle, and a single AMH measurement can be used reliably in future studies to determine if fertility is suboptimal in young adult cattle with low circulating AMH concentrations and a correspondingly diminished ovarian reserve.Keywords
This publication has 90 references indexed in Scilit:
- Inherent capacity of the pituitary gland to produce gonadotropins is not influenced by the number of ovarian follicles ≥3 mm in diameter in cattleReproduction, Fertility and Development, 2010
- Effect of the early-life nutritional environment on fecundity and fertility of mammalsPhilosophical Transactions Of The Royal Society B-Biological Sciences, 2009
- The developmental origins of adult disease (Barker) hypothesisAustralian and New Zealand Journal of Obstetrics and Gynaecology, 2006
- Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and ProgrammingPhysiological Reviews, 2005
- Living with the Past: Evolution, Development, and Patterns of DiseaseScience, 2004
- Superovulatory Response of One Ovary Is Related to the Micro- and Macroscopic Population of Follicles in the Contralateral Ovary of the CowBiology of Reproduction, 1999
- Age effects of follicle-stimulating hormone and pulsatile luteinizing hormone secretion across the menstrual cycle of premenopausal womenJournal of Clinical Endocrinology & Metabolism, 1996
- The effect of nutrition of the fetus and neonate on cardiovascular disease in adult lifeProceedings Of The Nutrition Society, 1992
- Oogenesis and ovarian development in the prenatal pigThe Anatomical Record, 1968
- QUANTITATIVE MORPHOLOGICAL INVESTIGATIONS OF THE FOLLICULAR SYSTEM IN WOMENCells Tissues Organs, 1952