Recovery of Prostaglandins in Human Cutaneous Inflammation
- 1 May 1971
- Vol. 2 (5756), 258-260
- https://doi.org/10.1136/bmj.2.5756.258
Abstract
An in-vivo skin perfusion technique has been used to study the pharmacological activity in inflamed skin of patients with allergic contact eczema. Perfusates from 35 out of 45 patients contained a smooth-muscle-contracting agent with prostaglandin-like properties. Solvent partition followed by thinlayer chromatography revealed this activity to be due to a mixture of prostaglandins E and F. This direct evidence supports the view that prostaglandins mediate inflammation in man.This publication has 9 references indexed in Scilit:
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