Genetic Defect in Biosynthesis of the Precursor Form of the Fourth Component of Complement
- 6 January 1978
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 199 (4324), 69-70
- https://doi.org/10.1126/science.199.4324.69
Abstract
Under cell-free conditions, liver polysomes from guinea pigs genetically deficient in the fourth component of complement (C4) did not synthesize pro-C4 (the precursor of C4), but did synthesize nascent C4 polypeptides which remained polysome bound. The defect was specific for pro-C4 synthesis since the amounts of total protein and albumin synthesis and release from C4-deficient polysomes were similar to that in normal guinea pig liver polysomes.Keywords
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