RNA Virus Evolution via a Fitness-Space Model
- 3 June 1996
- journal article
- research article
- Published by American Physical Society (APS) in Physical Review Letters
- Vol. 76 (23), 4440-4443
- https://doi.org/10.1103/physrevlett.76.4440
Abstract
We present a mean-field theory for the evolution of RNA virus populations. The theory operates with a distribution of the population in a one-dimensional fitness space, and is valid for sufficiently smooth fitness landscapes. Our approach explains naturally the recent experimental observation [I. S. Novella et al., Proc. Natl. Acad. Sci. U.S.A. 92, 5841–5844 (1995)] of two distinct stages in the growth of virus fitness.Keywords
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