The Effects of Virgin Coconut Oil on Bone Oxidative Status in Ovariectomised Rat
Open Access
- 1 January 2012
- journal article
- research article
- Published by Hindawi Limited in Evidence-Based Complementary and Alternative Medicine
- Vol. 2012, 1-6
- https://doi.org/10.1155/2012/525079
Abstract
Virgin coconut oil (VCO) was found to have antioxidant property due to its high polyphenol content. The aim of this study was to investigate the effect of the virgin coconut oil on lipid peroxidation in the bone of an osteoporotic rat model. Normal female Sprague-Dawley rats aged 3 months old were randomly divided into 4 groups, with 8 rats in each group: baseline, sham, ovariectomised (OVX) control group, and OVX given 8% VCO in the diet for six weeks. The oxidative status of the bone was assessed by measuring the index of lipid peroxidation, which is malondialdehyde (MDA) concentration, as well as the endogenous antioxidant enzymes glutathione peroxidase (GPX) and superoxide dismutase (SOD) in the tibia at the end of the study. The results showed that there was a significant decrease in MDA levels in the OVX-VCO group compared to control group. Ovariectomised rats treated with VCO also had significantly higher GPX concentration. The SOD level seemed to be increased in the OVX-VCO group compared to OVX-control group. In conclusion, VCO prevented lipid peroxidation and increased the antioxidant enzymes in the osteoporotic rat model.Keywords
Funding Information
- University Kebangsaan Malaysia (UKM-DLP-2011-067)
This publication has 37 references indexed in Scilit:
- Update on Bone Anabolics in Osteoporosis Treatment: Rationale, Current Status, and PerspectivesJournal of Clinical Endocrinology & Metabolism, 2012
- From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of OsteoporosisEndocrine Reviews, 2010
- Variation of phenolic content in coconut oil extracted by two conventional methodsInternational Journal of Food Science & Technology, 2008
- Virgin coconut oil supplemented diet increases the antioxidant status in ratsFood Chemistry, 2006
- Lipid peroxidation: Mechanisms, inhibition, and biological effectsBiochemical and Biophysical Research Communications, 2005
- Transient Changes in Oxygen Tension Inhibit Osteogenic Differentiation and Runx2 Expression in OsteoblastsOnline Journal of Public Health Informatics, 2004
- Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-κBBiochemical and Biophysical Research Communications, 2004
- Selenoproteins Are Expressed in Fetal Human Osteoblast-like CellsBiochemical and Biophysical Research Communications, 1998
- Antioxidant properties of phenolic compoundsTrends in Plant Science, 1997
- Nitroblue tetrazolium reduction and bone resorption by osteoclasts in vitro inhibited by a manganese-based superoxide dismutase mimicJournal of Bone and Mineral Research, 1992