Panorganismal Gut Microbiome−Host Metabolic Crosstalk
- 13 March 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Proteome Research
- Vol. 8 (4), 2090-2105
- https://doi.org/10.1021/pr801068x
Abstract
Coevolution shapes interorganismal crosstalk leading to profound and diverse cellular and metabolic changes as observed in gut dysbiosis in human diseases. Here, we modulated a simplified gut microbiota using pro-, pre-, and synbiotics to assess the depth of systemic metabolic exchanges in mice, using a multicompartmental modeling approach with metabolic signatures from 10 tissue/fluid compartments. The nutritionally induced microbial changes modulated host lipid, carbohydrate, and amino acid metabolism at a panorganismal scale. Galactosyl-oligosaccharides reduced lipogenesis, triacylglycerol incorporation into lipoproteins and triglyceride concentration in the liver and the kidney. Those changes were not correlated with decreased plasma lipoproteins that were specifically induced by L. rhamnosus supplementation. Additional alteration of transmethylation metabolic pathways (homocysteine-betaine) was observed in the liver and the pancreas following pre- and synbiotic microbial modulation, which may be of interest for control of glucose metabolism and insulin sensitivity. Probiotics also reduced hepatic glycogen and glutamine and adrenal ascorbate with inferred effects on energy homeostasis, antioxidation, and steroidogenesis. These studies show the breadth and the depth of gut microbiome modulations of host biochemistry and reveal that major mammalian metabolic processes are under symbiotic homeostatic control.This publication has 56 references indexed in Scilit:
- Evolution of Mammals and Their Gut MicrobesScience, 2008
- Symbiotic gut microbes modulate human metabolic phenotypesProceedings of the National Academy of Sciences of the United States of America, 2008
- Probiotic modulation of symbiotic gut microbial–host metabolic interactions in a humanized microbiome mouse modelMolecular Systems Biology, 2008
- Top‐down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse modelMolecular Systems Biology, 2008
- Development of the Human Infant Intestinal MicrobiotaPLoS Biology, 2007
- Kinetics and Metabolism of Bifidobacterium adolescentis MB 239 Growing on Glucose, Galactose, Lactose, and GalactooligosaccharidesApplied and Environmental Microbiology, 2007
- A top‐down systems biology view of microbiome‐mammalian metabolic interactions in a mouse modelMolecular Systems Biology, 2007
- An obesity-associated gut microbiome with increased capacity for energy harvestNature, 2006
- Global systems biology, personalized medicine and molecular epidemiologyMolecular Systems Biology, 2006
- Role of gastrointestinal factors in hunger and satiety in manProceedings Of The Nutrition Society, 1992