Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
Open Access
- 1 September 2013
- journal article
- review article
- Published by Taylor & Francis Ltd in OncoTargets and Therapy
- Vol. 6, 1249-1259
- https://doi.org/10.2147/ott.s36162
Abstract
Abstract: Notch signaling is an evolutionarily conserved pathway involved in cell fate control during development, stem cell self-renewal, and postnatal tissue differentiation. Roles for Notch in carcinogenesis, the biology of cancer stem cells, tumor angiogenesis, and epithelial-to-mesenchymal transition (EMT) have been reported. This review describes the role of Notch in the “stemness” program in cancer cells and in metastases, together with a brief update on the Notch inhibitors currently under investigation in oncology. These agents may be useful in targeting cancer stem cells and to reverse the EMT process.Keywords
This publication has 100 references indexed in Scilit:
- Cross-talk between miRNA and Notch signaling pathways in tumor development and progressionCancer Letters, 2010
- Direct inhibition of the NOTCH transcription factor complexNature, 2009
- Repair of Tissues by Adult Stem/Progenitor Cells (MSCs): Controversies, Myths, and Changing ParadigmsMolecular Therapy, 2009
- Emerging role of Notch in stem cells and cancerCancer Letters, 2008
- The tumor microenvironment and its role in promoting tumor growthOncogene, 2008
- Microenvironmental regulation of metastasisNature Reviews Cancer, 2008
- Activity of lapatinib a novel HER2 and EGFR dual kinase inhibitor in human endometrial cancer cellsBritish Journal of Cancer, 2008
- Dimorphic effects of Notch signaling in bone homeostasisNature Medicine, 2008
- Comparative Analysis of the Human and Mouse Hey1 Promoter: Hey Genes Are New Notch Target GenesBiochemical and Biophysical Research Communications, 2000
- Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arraysOncogene, 2000