Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative Diseases
- 11 February 2016
- journal article
- review article
- Published by SAGE Publications in Veterinary Pathology
- Vol. 53 (2), 327-348
- https://doi.org/10.1177/0300985815623997
Abstract
According to the WHO, the proportion of people over 60 years is increasing and expected to reach 22% of total world’s population in 2050. In parallel, recent animal demographic studies have shown that the life expectancy of pet dogs and cats is increasing. Brain aging is associated not only with molecular and morphological changes but also leads to different degrees of behavioral and cognitive dysfunction. Common age-related brain lesions in humans include brain atrophy, neuronal loss, amyloid plaques, cerebrovascular amyloid angiopathy, vascular mineralization, neurofibrillary tangles, meningeal osseous metaplasia, and accumulation of lipofuscin. In aging humans, the most common neurodegenerative disorder is Alzheimer’s disease (AD), which progressively impairs cognition, behavior, and quality of life. Pathologic changes comparable to the lesions of AD are described in several other animal species, although their clinical significance and effect on cognitive function are poorly documented. This review describes the commonly reported age-associated neurologic lesions in domestic and laboratory animals and the relationship of these lesions to cognitive dysfunction. Also described are the comparative interspecies similarities and differences to AD and other human neurodegenerative diseases including Parkinson’s disease and progressive supranuclear palsy, and the spontaneous and transgenic animal models of these diseases.Keywords
This publication has 101 references indexed in Scilit:
- Protein aggregation in amyotrophic lateral sclerosisActa Neuropathologica, 2013
- Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer’s disease, and dementia with Lewy bodiesActa Neuropathologica, 2010
- Knock-out and transgenic mouse models of tauopathiesNeurobiology of Aging, 2009
- Tauopathy with paired helical filaments in an aged chimpanzeeJournal of Comparative Neurology, 2008
- Region specific neuron loss in the aged canine hippocampus is reduced by enrichmentNeurobiology of Aging, 2008
- Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive functionNeurobiology of Learning and Memory, 2007
- Aging of the nigrostriatal system in the squirrel monkeyJournal of Comparative Neurology, 2004
- Carboxyl end-specific monoclonal antibodies to amyloid β protein (Aβ) subtypes (Aβ40 and Aβ42(43)) differentiate Aβ in senile plaques and amyloid angiopathy in brains of aged cynomolgus monkeysNeuroscience Letters, 1995
- Neuropathological stageing of Alzheimer-related changesActa Neuropathologica, 1991
- Neuromelanic pigment in substantia nigra neurons of rats and dogsNeuroscience Letters, 1986