Chlorotrimethylsilane Mediated Formation of ω-Allyl Esters of Aspartic And Glutamic Acids
- 1 November 1990
- journal article
- research article
- Published by Taylor & Francis Ltd in Synthetic Communications
- Vol. 20 (20), 3157-3160
- https://doi.org/10.1080/00397919008051540
Abstract
The protection of the ω-carboxylic function of aspartic and glutamic acids by an allyl ester is advantageous because of its orthogonality with most protecting groups and its compatibility with a number of reagents. In this communication we describe a simple method using chlorotrimethylsilane in the presence of allyl alcohol which gives exclusively the ω-allyl esters of both aspartic and glutamic acids in excellent yield.Keywords
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