Diblock Copolymer Micellar Nanoparticles Decorated with Annexin-A5 Proteins
- 22 June 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (28), 9010-9011
- https://doi.org/10.1021/ja062408n
Abstract
The formation of protein-decorated nanosized polymeric particles is described. Annexin-A5 protein binding to micellar aggregates having poly((1-ethoxycarbonyl)vinylphosphonic diacid) (PECVPD) and poly(n-butyl acrylate) (PBuA) as corona- and core-forming segments, respectively, was evidenced by Static and Dynamic Light Scattering (SDLS), cryo-Transmission Electron Microscopy (cryo-TEM), and Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) experiments. These new objects find potential applications, for example, in micelle-mediated target drug delivery and controlled fabrication of biochips.Keywords
This publication has 17 references indexed in Scilit:
- Bioresorbable Vesicles Formed through Spontaneous Self-Assembly of Amphiphilic Poly(ethylene oxide)-block-polycaprolactoneMacromolecules, 2006
- Counting Heads in the War against Cancer: Defining the Role of Annexin A5 Imaging in Cancer Treatment and SurveillanceCancer Research, 2006
- pH-Sensitive Vesicles Based on a Biocompatible Zwitterionic Diblock CopolymerJournal of the American Chemical Society, 2005
- Toward ‘smart’ nano-objects by self-assembly of block copolymers in solutionProgress in Polymer Science, 2005
- Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug deliveryMolecular BioSystems, 2005
- Atom Transfer Radical Polymerization of Dimethyl(1-ethoxycarbonyl)vinyl Phosphate and Corresponding Block CopolymersMacromolecules, 2005
- Micellization of block copolymersProgress in Polymer Science, 2003
- The dawning era of polymer therapeuticsNature Reviews Drug Discovery, 2003
- Surface Topography of the p3 and p6 Annexin V Crystal Forms Determined by Atomic Force MicroscopyJournal of Structural Biology, 2000
- Polymer vesicles in various mediaCurrent Opinion in Colloid & Interface Science, 2000