MicroRNAs in Vascular and Metabolic Disease
- 3 February 2012
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation Research
- Vol. 110 (3), 508-522
- https://doi.org/10.1161/circresaha.111.247445
Abstract
Recent findings demonstrated the importance of microRNAs (miRNAs) in the vasculature and the orchestration of lipid metabolism and glucose homeostasis. MiRNA networks represent an additional layer of regulation for gene expression that absorbs perturbations and ensures the robustness of biological systems. This function is very elegantly demonstrated in cholesterol metabolism where miRNAs reducing cellular cholesterol export are embedded in the very same genes that increase cholesterol synthesis. Often their alteration does not affect normal development but changes under stress conditions and in disease. A detailed understanding of the molecular and cellular mechanisms of miRNA-mediated effects on metabolism and vascular pathophysiology could pave the way for the development of novel diagnostic markers and therapeutic approaches. In the first part of this review, we summarize the role of miRNAs in vascular and metabolic diseases and explore potential confounding effects by platelet miRNAs in preclinical models of cardiovascular disease. In the second part, we discuss experimental strategies for miRNA target identification and the challenges in attributing miRNA effects to specific cell types and single targets.Keywords
This publication has 124 references indexed in Scilit:
- The Lin28/let-7 Axis Regulates Glucose MetabolismCell, 2011
- A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?Cell, 2011
- Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIPCell, 2010
- The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese miceBiochemical and Biophysical Research Communications, 2009
- microRNA-221 regulates high glucose-induced endothelial dysfunctionBiochemical and Biophysical Research Communications, 2009
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- miR-126 Regulates Angiogenic Signaling and Vascular IntegrityDevelopmental Cell, 2008
- The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and AngiogenesisDevelopmental Cell, 2008
- Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA ClustersCell, 2008
- Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR EvolutionCell, 2005