Gastric GIST malignancy evaluated by18FDG-PET as compared with EUS-FNA and endoscopic biopsy
- 1 January 2007
- journal article
- research article
- Published by Taylor & Francis Ltd in Scandinavian Journal of Gastroenterology
- Vol. 42 (5), 633-641
- https://doi.org/10.1080/00365520601040450
Abstract
The usefulness of 18F-fluoro-2-deoxyglucose positron emission tomography (18FDG-PET), whose high rate of FDG accumulation indicates high metabolism and malignant potential, has already been reported. The aims of this study were to evaluate the malignancy of primary gastrointestinal stromal tumour (GIST) in the stomach by 18FDG-PET and to correlate the FDG uptake values with known risk factors as determined by histology after EUS-guided fine needle aspiration (EUS-FNA) or endoscopic biopsy. Of 29 patients with histologically proven GI-mesenchymal tumours, 21 with gastric GISTs underwent 18FDG-PET. Tumour size, mitotic index, Ki-67 labelling index (LI) and cellularity of the tumour tissue were compared with the standardized uptake value (SUV) of FDG. Strong correlations were found between the SUV of FDG and EUS size, and mitotic index of EUS-FNA specimens (tumour size versus SUV, p=0.004, r=0.542; number of mitotic cells versus SUV, p=0.0078; n=21). Moreover, we examined the association between SUV and risk categories based on EUS-FNA findings using ROC curves. The cut-off values of FDG SUV were 2.2, 4.2 and 6.5 for the very low-, low-, intermediate- and high-risk groups, respectively. 18FDG-PET may be used to assess malignancy of GISTs. This image modality helps us determine the management strategy for these patients and complements the information on the biological behaviour and cellular proliferation of the tumours.Keywords
This publication has 24 references indexed in Scilit:
- Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate eraCancer, 2005
- Endoscopic ultrasonography-guided fine needle aspiration biopsy in follow-up patients with gastrointestinal stromal tumoursEuropean Journal of Gastroenterology & Hepatology, 2003
- Gain-of-function mutations of platelet-derived growth factor receptor α gene in gastrointestinal stromal tumorsGastroenterology, 2003
- Gastrointestinal Stromal Tumors, Intramural Leiomyomas, and Leiomyosarcomas in the Rectum and AnusThe American Journal of Surgical Pathology, 2001
- Prognosis of Gastrointestinal Smooth-Muscle (Stromal) TumorsThe American Journal of Surgical Pathology, 1999
- Preliminary Results of Fine Needle Aspiration Biopsy Histology in Upper Gastrointestinal Submucosal TumorsEndoscopy, 1998
- Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal TumorsScience, 1998
- Stromal Tumors of the Jejunum and IleumThe American Journal of Surgical Pathology, 1997
- Stromal Tumors of the Duodenum A Histologic and Immunohistochemical Study of 20 CasesThe American Journal of Surgical Pathology, 1995
- Enzymology of Cancer CellsThe New England Journal of Medicine, 1977