Intravenous Immunoglobulin in the Treatment of Primary Immunodeficiency Diseases
- 1 January 2017
- journal article
- Published by SLACK, Inc. in Pediatric Annals
- Vol. 46 (1), e8-e12
- https://doi.org/10.3928/19382359-20161213-03
Abstract
Intravenous immunoglobulin (IVIG) has been used as antibody replacement therapy in primary immunodeficiency diseases (PIDDs) for more than 50 years. Its role as a therapeutic agent has expanded over the past couple of decades as its anti-inflammatory and immune-modulatory mechanisms of action have been elucidated. It is now used "off-label" to treat other autoimmune diseases. This article focuses on the role of IVIG in the treatment of PIDDs characterized by absent or deficient antibody production. Replacement doses are given on a monthly basis in these conditions as a prophylactic measure to prevent acute and serious bacterial infections. [Pediatr Ann. 2017;46(1):e8-e12.].Keywords
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