Atherosclerosis as a disease of failed endogenous repair
- 1 January 2008
- journal article
- review article
- Published by IMR Press in Frontiers in Bioscience-Landmark
- Vol. ume (13), 3621-36
- https://doi.org/10.2741/2954
Abstract
As coronary artery disease (CAD) continues to be the primary cause of mortality, a more in-depth understanding of pathophysiology and novel treatments are being sought. The past two decades have established inflammation as a driving force behind CAD--from endothelial dysfunction to heart failure. Recent advances in stem/progenitor cell biology have led to initial applications of progenitor cells in CAD continuum and have revealed that atherosclerosis is, at least in part, a disease of failed endogenous vascular repair. Several key progenitor cell populations including endothelial progenitor cells (AC133+/CD34+ population), vascular progenitors (CD31+/CD45(low) population), KDR+ cells and other bone marrow subtypes are mobilized for vascular repair. However, age and risk factors negatively impact these cells even prior to clinical CAD. Sex-based differences in progenitor cell capacity for repair have emerged as a new research focus that may offer mechanistic insights into clinical CAD discrepancies between men and women. Quantifying injury and cell-based repair and better defining their interactions should enable us to halt or even prevent CAD by enhancing the repair side of the repair/injury equation.Keywords
This publication has 100 references indexed in Scilit:
- Circulating endothelial progenitor cells predict coronary artery disease severityAmerican Heart Journal, 2006
- Circulating endothelial progenitor cell deficiency contributes to impaired arterial elasticity in persons of advancing ageJournal of Human Hypertension, 2006
- Insights From the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study: Part II: Gender Differences in Presentation, Diagnosis, and Outcome With Regard to Gender-Based Pathophysiology of Atherosclerosis and Macrovascular and Microvascular Coronary DiseaseJournal of the American College of Cardiology, 2006
- Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic MechanismsNature Reviews Drug Discovery, 2005
- Atherosclerosis 2005Circulation, 2005
- Age- and gender-related alterations of the number and clonogenic capacity of circulating CD34+ progenitor cellsBiogerontology, 2005
- Risk factors for coronary artery disease, circulating endothelial progenitor cells, and the role of HMG-CoA reductase inhibitorsKidney International, 2005
- Inflammation, Atherosclerosis, and Coronary Artery DiseaseThe New England Journal of Medicine, 2005
- CARDIAC ALLOGRAFT REJECTION LATE AFTER TRANSPLANTATION IS A RISK FACTOR FOR GRAFT CORONARY ARTERY DISEASETransplantation, 1998
- The pathogenesis of atherosclerosis: a perspective for the 1990sNature, 1993