Seco[d-Asp3]microcystin-RR and [d-Asp3,d-Glu(OMe)6]microcystin-RR, Two New Microcystins from a Toxic Water Bloom of the Cyanobacterium Planktothrix rubescens
- 21 January 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 67 (3), 337-342
- https://doi.org/10.1021/np034036r
Abstract
Two novel microcystins, seco[d-Asp3]microcystin-RR (1) and [d-Asp3,d-Glu(OMe)6]-microcystin-RR (2), along with the known [d-Asp3]microcystin-RR (3), were isolated from a Planktothrix rubescens toxic bloom collected in Lake Bled, Slovenia. The structures were deduced using one- and two-dimensional NMR techniques, ESIMS/CID/MS analysis, and Marfey's method for determining the amino acids' absolute stereochemistry. Compounds 1 and 3 exhibit weak PP1 inhibitory activity. The NMR data of compound 3 are reported here for the first time.Keywords
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