Synthesizing epidemiological and economic optima for control of immunizing infections
Open Access
- 8 August 2011
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 108 (34), 14366-14370
- https://doi.org/10.1073/pnas.1101694108
Abstract
Epidemic theory predicts that the vaccination threshold required to interrupt local transmission of an immunizing infection like measles depends only on the basic reproductive number and hence transmission rates. When the search for optimal strategies is expanded to incorporate economic constraints, the optimum for disease control in a single population is determined by relative costs of infection and control, rather than transmission rates. Adding a spatial dimension, which precludes local elimination unless it can be achieved globally, can reduce or increase optimal vaccination levels depending on the balance of costs and benefits. For weakly coupled populations, local optimal strategies agree with the global cost-effective strategy; however, asymmetries in costs can lead to divergent control optima in more strongly coupled systems—in particular, strong regional differences in costs of vaccination can preclude local elimination even when elimination is locally optimal. Under certain conditions, it is locally optimal to share vaccination resources with other populations.Keywords
This publication has 44 references indexed in Scilit:
- Searching for the most cost-effective strategy for controlling epidemics spreading on regular and small-world networksJournal of The Royal Society Interface, 2011
- Game Theory of Social Distancing in Response to an EpidemicPLoS Computational Biology, 2010
- Optimizing Influenza Vaccine DistributionScience, 2009
- Optimal control of epidemics in metapopulationsJournal of The Royal Society Interface, 2009
- Optimizing the control of disease infestations at the landscape scaleProceedings of the National Academy of Sciences of the United States of America, 2007
- Stochastic amplification in epidemicsJournal of The Royal Society Interface, 2006
- Modelling vaccination strategies against foot-and-mouth diseaseNature, 2002
- Vaccines should be kept even if polio is wiped outNature, 2002
- Cost Optimization in the SIS Model of Infectious Disease with TreatmentTopics in Economic Analysis & Policy, 2002
- Optimal Control of Some Simple Deterministic Epidemic ModelsJournal of the Operational Research Society, 1978