Effects of dietary supplementation with antimicrobial peptide‐P5 on growth performance, apparent total tract digestibility, faecal and intestinal microflora and intestinal morphology of weanling pigs
- 20 August 2012
- journal article
- research article
- Published by Wiley in Journal of the Science of Food and Agriculture
- Vol. 93 (3), 587-592
- https://doi.org/10.1002/jsfa.5840
Abstract
BACKGROUND: The increase in drug-resistant bacteria and the ban on antibiotic growth promoters worldwide make the search for novel means of preventing bacterial infection and promoting growth performance imperative. In this sense, antimicrobial peptides are thought to be ideal candidates owing to their antimicrobial properties, broad spectrum of activity and low propensity for development of bacterial resistance. The aim of the present study was to investigate the effect of dietary supplementation with antimicrobial peptide-P5 (AMP-P5) on weanling pig nutrition. RESULTS: A total of 240 weanling pigs were allotted to four treatments on the basis of initial body weight. There were four replicates in each treatment, with 15 pigs per replicate. Dietary treatments were negative control (NC, basal diet without antimicrobial), positive control (PC, basal diet + 1.5 g kg−1 apramycin), basal diet with 40 mg kg−1 AMP-P5 (P5-40) and basal diet with 60 mg kg−1 AMP-P5 (P5-60). Pigs fed the PC or P5-60 diet showed improved (P < 0.05) overall growth performance, apparent total tract digestibility of dry matter, crude protein and gross energy and reduced (P < 0.05) faecal and intestinal coliforms compared with pigs fed the NC diet. CONCLUSION: The results obtained in this study indicate that dietary supplementation with 60 mg kg−1 AMP-P5 has the potential to improve the growth performance and apparent total tract digestibility of nutrients and reduce coliforms in weanling pigs. © 2012 Society of Chemical IndustryKeywords
This publication has 21 references indexed in Scilit:
- Potato (Solanum tuberosum L. cv. Gogu valley) protein as a novel antimicrobial agent in weanling pigs1Journal of Animal Science, 2008
- Effects of potato (Solanum tuberosum L. cv. Golden valley) protein having antimicrobial activity on the growth performance, and intestinal microflora and morphology in weanling pigsAnimal Feed Science and Technology, 2008
- Effects of the lactoferrin (LF) on the growth performance, intestinal microflora and morphology of weanling pigsAnimal Feed Science and Technology, 2007
- Effects of supplementation of β-glucans on growth performance, nutrient digestibility, and immunity in weanling pigsJournal of Animal Science, 2006
- Synergism of Leu–Lys rich antimicrobial peptides and chloramphenicol against bacterial cellsBiochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2006
- Effect of fishmeal replacement with spray-dried animal plasma and colistin on intestinal structure, intestinal microbiology, and performance of weanling pigs challenged with Escherichia coli K991Journal of Animal Science, 2003
- Antimicrobial peptides of multicellular organismsNature, 2002
- Use of antimicrobial agents in veterinary medicine and food animal productionInternational Journal of Antimicrobial Agents, 2001
- Solid Phase SynthesisScience, 1986
- AN IMPROVED PROCEDURE FOR THE DETERMINATION OF CHROMIC OXIDE IN FEED AND FECESCanadian Journal of Animal Science, 1979