Current Review of Iron Overload and Related Complications in Hematopoietic Stem Cell Transplantation
Open Access
- 1 March 2017
- journal article
- review article
- Published by Galenos Yayinevi in Turkish Journal of Haematology : Official Journal of Turkish Society of Haematology
- Vol. 34 (1), 1-9
- https://doi.org/10.4274/tjh.2016.0450
Abstract
Iron overload is an adverse prognostic factor for patients undergoing hematopoietic stem cell transplantation (HSCT). In the HSCT setting, pretransplant and early posttransplant ferritin and transferrin saturation were found to be highly elevated due to high transfusion requirements. In addition to that, post-HSCT iron overload was shown to be related to infections, hepatic sinusoidal obstruction syndrome, mucositis, liver dysfunction, and acute graft-versus-host disease. Hyperferritinemia causes decreased survival rates in both pre- and posttransplant settings. Serum ferritin levels, magnetic resonance imaging, and liver biopsy are diagnostic tools for iron overload. Organ dysfunction due to iron overload may cause high mortality rates and therefore sufficient iron chelation therapy is recommended in this setting. In this review the management of iron overload in adult HSCT is discussed.Keywords
This publication has 68 references indexed in Scilit:
- Recommended Screening and Preventive Practices for Long-Term Survivors after Hematopoietic Cell TransplantationTransplantation and Cellular Therapy, 2012
- Hematologic responses to deferasirox therapy in transfusion-dependent patients with myelodysplastic syndromesHaematologica, 2012
- Does iron overload really matter in stem cell transplantation?American Journal of Hematology, 2012
- High ferritin levels are associated with hepatosplenic candidiasis in hematopoietic stem cell transplant candidatesInternational Journal of Infectious Diseases, 2010
- Iron metabolism and ineffective erythropoiesis in β-thalassemia mouse modelsAnnals of the New York Academy of Sciences, 2010
- Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cellsBlood, 2009
- Ferritin for the clinicianBlood Reviews, 2009
- Iron overload in hematopoietic cell transplantationBone Marrow Transplantation, 2008
- Correction of anemia in a transfusion‐dependent patient with primary myelofibrosis receiving iron chelation therapy with deferasirox (Exjade®, ICL670)European Journal of Haematology, 2007
- Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantationBlood, 2007