Isolated Failure of Autonomic Noradrenergic Neurotransmission
- 5 June 1986
- journal article
- case report
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 314 (23), 1494-1497
- https://doi.org/10.1056/nejm198606053142307
Abstract
AUTONOMIC disorders are usually characterized by widespread abnormalities in both the sympathetic and the parasympathetic systems; this is true whether the autonomic disorder is associated with central neurologic deficits or is confined to the peripheral autonomic nervous system.1 2 3 Detailed testing can usually identify the extent of the autonomic neuronal damage,4 , 5 but it is uncommon for the abnormality to be localized to a single class of neurons. We have recently evaluated a young woman with autonomic failure in whom the pathophysiologic features of the disorder suggest an isolated failure in the β-hydroxylation of dopamine in the peripheral noradrenergic nerves.Case Report . . .Keywords
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