Gain control by layer six in cortical circuits of vision
Top Cited Papers
- 22 February 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 483 (7387), 47-52
- https://doi.org/10.1038/nature10835
Abstract
After entering the cerebral cortex, sensory information spreads through six different horizontal neuronal layers that are interconnected by vertical axonal projections. It is believed that through these projections layers can influence each other's response to sensory stimuli, but the specific role that each layer has in cortical processing is still poorly understood. Here we show that layer six in the primary visual cortex of the mouse has a crucial role in controlling the gain of visually evoked activity in neurons of the upper layers without changing their tuning to orientation. This gain modulation results from the coordinated action of layer six intracortical projections to superficial layers and deep projections to the thalamus, with a substantial role of the intracortical circuit. This study establishes layer six as a major mediator of cortical gain modulation and suggests that it could be a node through which convergent inputs from several brain areas can regulate the earliest steps of cortical visual processing.Keywords
This publication has 50 references indexed in Scilit:
- Multiple Clusters of Release Sites Formed by Individual Thalamic Afferents onto Cortical Interneurons Ensure Reliable TransmissionNeuron, 2011
- Broadly Tuned Response Properties of Diverse Inhibitory Neuron Subtypes in Mouse Visual CortexNeuron, 2010
- Lateral competition for cortical space by layer-specific horizontal circuitsNature, 2010
- High-performance genetically targetable optical neural silencing by light-driven proton pumpsNature, 2010
- KCC2 Expression Promotes the Termination of Cortical Interneuron Migration in a Voltage-Sensitive Calcium-Dependent MannerNeuron, 2009
- Emerging views of corticothalamic functionCurrent Opinion in Neurobiology, 2008
- Highly Selective Receptive Fields in Mouse Visual CortexJournal of Neuroscience, 2008
- Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortexNature Reviews Neuroscience, 2008
- Corticothalamic feedback enhances stimulus response precision in the visual systemProceedings of the National Academy of Sciences of the United States of America, 2007
- Channelrhodopsin-2, a directly light-gated cation-selective membrane channelProceedings of the National Academy of Sciences of the United States of America, 2003