Metallic Copper as an Antimicrobial Surface
Top Cited Papers
Open Access
- 1 March 2011
- journal article
- review article
- Published by American Society for Microbiology in Applied and Environmental Microbiology
- Vol. 77 (5), 1541-1547
- https://doi.org/10.1128/aem.02766-10
Abstract
Bacteria, yeasts, and viruses are rapidly killed on metallic copper surfaces, and the term “contact killing” has been coined for this process. While the phenomenon was already known in ancient times, it is currently receiving renewed attention. This is due to the potential use of copper as an antibacterial material in health care settings. Contact killing was observed to take place at a rate of at least 7 to 8 logs per hour, and no live microorganisms were generally recovered from copper surfaces after prolonged incubation. The antimicrobial activity of copper and copper alloys is now well established, and copper has recently been registered at the U.S. Environmental Protection Agency as the first solid antimicrobial material. In several clinical studies, copper has been evaluated for use on touch surfaces, such as door handles, bathroom fixtures, or bed rails, in attempts to curb nosocomial infections. In connection to these new applications of copper, it is important to understand the mechanism of contact killing since it may bear on central issues, such as the possibility of the emergence and spread of resistant organisms, cleaning procedures, and questions of material and object engineering. Recent work has shed light on mechanistic aspects of contact killing. These findings will be reviewed here and juxtaposed with the toxicity mechanisms of ionic copper. The merit of copper as a hygienic material in hospitals and related settings will also be discussed.Keywords
This publication has 41 references indexed in Scilit:
- Bacterial Killing by Dry Metallic Copper SurfacesApplied and Environmental Microbiology, 2011
- Metallic copper corrosion rates, moisture content, and growth medium influence survival of copper ion-resistant bacteriaApplied Microbiology and Biotechnology, 2010
- Isolation and Characterization of Bacteria Resistant to Metallic Copper SurfacesApplied and Environmental Microbiology, 2010
- Role of copper in reducing hospital environment contaminationJournal of Hospital Infection, 2010
- Genes involved in copper resistance influence survival ofPseudomonas aeruginosaon copper surfacesJournal of Applied Microbiology, 2009
- Copper methanobactin: a molecule whose time has comeCurrent Opinion in Chemical Biology, 2008
- Importance of the environment in meticillin-resistant Staphylococcus aureus acquisition: the case for hospital cleaningThe Lancet Infectious Diseases, 2008
- Potential use of copper as a hygienic surface; problems associated with cumulative soiling and cleaningJournal of Hospital Infection, 2007
- Molecular mechanisms of copper resistance and accumulation in bacteriaFEMS Microbiology Reviews, 1994
- Copper resistance in Pseudomonas syringae mediated by periplasmic and outer membrane proteins.Proceedings of the National Academy of Sciences of the United States of America, 1991