Folded cavity SOI microring sensors for high sensitivity and real time measurement of biomolecular binding
- 11 September 2008
- journal article
- Published by Optica Publishing Group in Optics Express
- Vol. 16 (19), 15137-15148
- https://doi.org/10.1364/oe.16.015137
Abstract
We demonstrate folded waveguide ring resonators for biomolecular sensing. We show that extending the ring cavity length increases the resonator quality factor, and thereby enhances the sensor resolution and minimum level of detection, while at the same time relaxing the tolerance on the coupling conditions to provide stable and large resonance contrast. The folded spiral path geometry allows a 1.2 mm long ring waveguide to be enclosed in a 150 µm diameter sensor area. The spiral cavity resonator is used to monitor the streptavidin protein binding with a detection limit of ~3 pg/mm2, or a total mass of ~5 fg. The real time measurements are used to analyze the kinetics of biotin-streptavidin binding.Keywords
This publication has 20 references indexed in Scilit:
- Label-Free, Single-Molecule Detection with Optical MicrocavitiesScience, 2007
- Silicon-on-Insulator microring resonator for sensitive and label-free biosensingOptics Express, 2007
- A Silicon-on-Insulator Photonic Wire Based Evanescent Field SensorIEEE Photonics Technology Letters, 2006
- Pathogen detection: A perspective of traditional methods and biosensorsBiosensors and Bioelectronics, 2006
- Optical sensing of biomolecules using microring resonatorsIEEE Journal of Selected Topics in Quantum Electronics, 2006
- SPR for molecular interaction analysis: a review of emerging application areasJournal of Molecular Recognition, 2004
- Integrated optics ring-resonator chemical sensor with polymer transduction layerElectronics Letters, 2004
- An integrated optical interferometric nanodevice based on silicon technology for biosensor applicationsNanotechnology, 2003
- Surface plasmon resonance sensors: reviewSensors and Actuators B: Chemical, 1999
- A fiber optic biosensor: combination tapered fibers designed for improved signal acquisitionBiosensors and Bioelectronics, 1993