The Survival-promoting Peptide Y-P30 Enhances Binding of Pleiotrophin to Syndecan-2 and -3 and Supports Its Neuritogenic Activity
Open Access
- 1 September 2008
- journal article
- Published by Elsevier BV in Journal of Biological Chemistry
- Vol. 283 (36), 25036-25045
- https://doi.org/10.1074/jbc.m800963200
Abstract
Y-P30 is a polypeptide produced by peripheral blood mononuclear cells of the maternal immune system during pregnancy. The peptide passes the blood-placenta barrier and accumulates in neurons of the developing infant brain, where it enhances survival of thalamic neurons and displays neuritogenic activities. In this study, we identify pleiotrophin (PTN) and syndecan-2 and -3 as direct binding partners of Y-P30. PTN is known to promote neurite outgrowth of thalamic neurons due to its association with the proteoglycan syndecan-3. Via spontaneous oligomerization Y-P30 can capture large macromolecular complexes containing PTN and potentially syndecans. Accordingly, the neuritogenic activity of Y-P30 in thalamic primary cultures requires the presence of PTN in the media and binding to syndecans. Thus, we propose that the neurite outgrowth promoting actions of Y-P30 during brain development are essentially based on its association with the PTN/syndecan signaling complex. This identifies a new mechanism of communication between the nervous and the immune system that might directly affect the wiring of the brain during development.Keywords
This publication has 48 references indexed in Scilit:
- Caldendrin–Jacob: A Protein Liaison That Couples NMDA Receptor Signalling to the NucleusPLoS Biology, 2008
- Involvement of phosphoinositide 3-kinase and Akt in the induction of muscle protein degradation by proteolysis-inducing factorBiochemical Journal, 2008
- Secretion of pleiotrophin stimulates breast cancer progression through remodeling of the tumor microenvironmentProceedings of the National Academy of Sciences of the United States of America, 2007
- Pleiotrophin is a neurotrophic factor for spinal motor neuronsProceedings of the National Academy of Sciences of the United States of America, 2007
- A maternal blood‐borne factor promotes survival of the developing thalamusThe FASEB Journal, 2004
- Proteolysis‐inducing factor regulates hepatic gene expression via the transcription factors NF‐κΒ and STAT3The FASEB Journal, 2001
- Cortactin-Src Kinase Signaling Pathway Is Involved in N-syndecan-dependent Neurite OutgrowthPublished by Elsevier BV ,1998
- N‐Syndecan and HB‐GAM (Heparin‐Binding Growth‐Associated Molecule) associate with early axonal tracts in the rat brainEuropean Journal of Neuroscience, 1998
- Developmentally regulated expression of pleiotrophin, a novel heparin binding growth factor, in the nervous system of the ratDevelopmental Brain Research, 1993
- Expression of the HBNF (heparin-binding neurite-promoting factor) gene in the brain of fetal, neonatal and adult rat: an in situ hybridization studyDevelopmental Brain Research, 1992