Extranodal nasal‐type natural killer/T‐cell lymphoma masquerading as recalcitrant sinusitis

Abstract

Background. Extranodal nasal‐type natural killer (NK)/T‐cell lymphoma is a very uncommon disease process often mimicking refractory sinusitis. The diagnosis may be discovered after an extensive exclusion process. Careful immunohistochemical evaluation is crucial to differentiate NK/T‐cell lymphoma from other malignancies. Methods and Results. We describe a 46‐year‐old white man presenting with a 4‐month history of refractory sinusitis and new onset visual field loss in his right eye, right facial tingling, and pain. Examination revealed right periorbital edema and scleritis, and necrotic appearing turbinates with purulence and fibrinous debris. CT/MRI delineated extensive paranasal sinus involvement. Immunohistopathology demonstrated extranodal nasal‐type NK/T‐cell lymphoma. Additional radiography revealed widespread involvement. Conclusion. Severe recalcitrant sinusitis with orbital involvement may be the initial presentation of NK/T‐cell lymphoma. Ulcerative or necrotic lesions in the midline of the head and neck should raise concern for this disease. In addition to radiographic and laboratory testing, large biopsies should be taken for immunohistochemical analysis to achieve diagnosis and guide further management. © 2009 Wiley Periodicals, Inc. Head Neck, 2010