The natural killer gene complex: a genetic basis for understanding natural killer cell function and innate immunity
- 1 February 1997
- journal article
- Published by Wiley in Immunological Reviews
- Vol. 155 (1), 53-65
- https://doi.org/10.1111/j.1600-065x.1997.tb00939.x
Abstract
Summary: The natural killer gene complex encodes proteins, some of which are structurally unrelated, that impact on NK-cell function. Detailed analyses have indicated that these molecules are involved in NK-cell recognition, activation, and inhibition. The importance of this genomic region is highlighted by studies indicating that NKC-associated genes significantly influence NK cell-mediated innate host defense against life-threatening pathogens and that the NKC is conserved among diverse species. Thus, further elucidation of the NKC and its gene products will provide a genetic basis for understanding innate immunity and NK-cell activity at the molecular level.Keywords
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