Human Genotoxicity: Pesticide Applicators and Phosphine
- 13 October 1989
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 246 (4927), 251-255
- https://doi.org/10.1126/science.2799386
Abstract
Fumigant applicators who, 6 weeks to 3 months earlier, were exposed to phosphine, a common grain fumigant, or to phosphine and other pesticides had significantly increased stable chromosome rearrangements, primarily translocations in G-banded lymphocytes. Less stable aberrations including chromatid deletions and gaps were significantly increased only during the application season, but not at this later time point. During fumigant application, measured exposure to phosphine exceeds accepted national standards. Because phosphine is also used as a dopant in the microchip industry and is generated in waste treatment, the possibility of more widespread exposure and long-term health sequelae must be considered.Keywords
This publication has 16 references indexed in Scilit:
- Phosphine Exposures in Grain Elevators during Fumigation with Aluminum PhosphideApplied Industrial Hygiene, 1988
- The frequency of chromosome aberrations in a control populationMutation Research/Environmental Mutagenesis and Related Subjects, 1987
- Chromosome aberrations in peripheral lymphocytes of male homosexualsCancer Genetics and Cytogenetics, 1985
- Cytogenetic variability of lymphocytes from phenotypically normal men: Influence of age, smoking, season, and sample storageJournal of Toxicology and Environmental Health, 1985
- Some experimental design and analysis considerations for cytogenetics studiesEnvironmental Mutagenesis, 1985
- Gas-chromatographic determination of phosphine in ambient airThe Analyst, 1978
- [Letters to nature]Nature, 1975
- [Letters to nature]Nature, 1975
- Non-random occurrence of 7–14 translocations in human lymphocyte culturesNature, 1975
- New Giemsa method for the differential staining of sister chromatidsNature, 1974