Effect of Bladder Outlet Obstruction on Micturition Reflex Pathways in the Rat
- 1 October 1988
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 140 (4), 864-871
- https://doi.org/10.1016/s0022-5347(17)41846-5
Abstract
The effect of outlet obstruction on neural pathways to the bladder was examined six weeks after urethral ligation in rats. Ligated rats exhibited a seven-fold increase in bladder weight, a six-fold increase in volume, and significant increases (p less than 0.001) in micturition pressure, residual volume and compliance measured under urethane anesthesia. Unanesthetized ligated rats in comparison to control rats voided smaller volumes of urine more frequently (0.7 vs 1.1 voids/hr., p less than 0.001). Electrophysiological examination of vesical afferent and efferent peripheral neural pathways in the pelvic and hypogastric nerves and sympathetic chain did not reveal any differences in thresholds, axonal conduction velocities or ganglionic transmission. A significant difference (p less than 0.05) was noted in the percentage of obstructed rats (100%) exhibiting a short latency spinal reflex as compared to controls (35%). The long latency supraspinal micturition reflex was similar in both groups. These data suggest that obstruction in rats is accompanied by some degree of neural plasticity resulting in a more prominent spinal reflex that could contribute to the development of the unstable bladder following obstruction in humans and unanesthetized animals.Keywords
This publication has 20 references indexed in Scilit:
- Cystometrical Evaluation of Bladder Instability in Rats with Infravesical Outflow ObstructionJournal of Urology, 1987
- Acute Biochemical and Functional Alterations in The Partially Obstructed Rabbit Urinary BladderJournal of Urology, 1986
- Functional Effects of in Vitro Obstruction on the Rabbit Urinary BladderJournal of Urology, 1986
- Transvesical Phenolisation of the Pelvic Plexuses: A Simple Technique for the Treatment of Refractory Detrusor Instability and HyperreflexiaUrologia Internationalis, 1986
- Experimental models of urinary bladder outlet obstructionNeurourology and Urodynamics, 1986
- Factors affecting detrusor contractilityNeurourology and Urodynamics, 1986
- Recovery From Short-Term Obstruction of the Rabbit Urinary BladderJournal of Urology, 1985
- An Experimental Model of Detrusor Instability in the Obstructed PigBritish Journal of Urology, 1985
- Smooth Muscle Cell Hypertrophy and Hyperplasia in the Rat Detrusor after Short-Time Infravesical Outflow ObstructionJournal of Urology, 1984
- Changes in Contractile Properties in Hypertrophic Rat Urinary BladderJournal of Urology, 1982