Early dynamics of transmission and control of COVID-19: a mathematical modelling study
Preprint
- 2 February 2020
- preprint
- other
- Published by Cold Spring Harbor Laboratory
Abstract
Background: An outbreak of the novel coronavirus SARS-CoV-2 has led to 46,997 confirmed cases as of 13th February 2020. Understanding the early transmission dynamics of the infection and evaluating the effectiveness of control measures is crucial for assessing the potential for sustained transmission to occur in new areas.Methods: We combined a stochastic transmission model with data on cases of novel coronavirus disease (COVID-19) in Wuhan and international cases that originated in Wuhan to estimate how transmission had varied over time during January and February 2020. Based on these estimates, we then calculated the probability that newly introduced cases might generate outbreaks in other areas.Findings: We estimated that the median daily reproduction number, Rt, declined from 2.35 (95% CI: 1.15-4.77) one week before travel restrictions were introduced on 23rd January to 1.05 (95% CI: 0.413-2.39) one week after. Based on our estimates of Rt,we calculated that in locations with similar transmission potential as Wuhan in early January, once there are at least four independently introduced cases, there is a more than 50% chance the infection will establish within that population.Interpretation: Our results show that COVID-19 transmission likely declined in Wuhan during late January 2020, coinciding with the introduction of control measures. As more cases arrive in international locations with similar transmission potential to Wuhan pre-control, it is likely many chains of transmission will fail to establish initially, but may still cause new outbreaks eventually.Funding: Wellcome Trust (206250/Z/17/Z, 210758/Z/18/Z), HDR UK (MR/S003975/1), Gates Foundation (INV-003174), NIHR (16/137/109)Keywords
Other Versions
- Published version: Version The Lancet Infectious Diseases, 20, preprints
This publication has 11 references indexed in Scilit:
- Transmission of 2019-nCoV Infection from an Asymptomatic Contact in GermanyThe New England Journal of Medicine, 2020
- Feasibility of controlling 2019-nCoV outbreaks by isolation of cases and contactsPublished by Cold Spring Harbor Laboratory ,2020
- Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020Eurosurveillance, 2020
- Novel coronavirus (2019-nCoV) early-stage importation risk to Europe, January 2020Eurosurveillance, 2020
- The RAPIDD Ebola forecasting challenge: Model description and synthetic data generationEpidemics, 2018
- The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmissionEurosurveillance, 2015
- Evaluation of the Benefits and Risks of Introducing Ebola Community Care Centers, Sierra LeoneEmerging Infectious Diseases, 2015
- Temporal Changes in Ebola Transmission in Sierra Leone and Implications for Control Requirements: a Real-time Modelling StudyPLoS Currents, 2015
- Ebola Virus Disease in West Africa — The First 9 Months of the Epidemic and Forward ProjectionsThe New England Journal of Medicine, 2014
- Superspreading and the effect of individual variation on disease emergenceNature, 2005