Dietary Fat Dose Dependently Increases Spontaneous Caloric Intake in Rat
- 1 July 2003
- journal article
- Published by Wiley in Obesity Research
- Vol. 11 (7), 859-864
- https://doi.org/10.1038/oby.2003.118
Abstract
To characterize the dose-response relationship between dietary fat to carbohydrate ratio and spontaneous caloric intake. Male Long-Evans rats consumed milk-based liquid diets that differed in fat content (17% to 60% of kilocalories) but had equivalent protein content and energy density. In Experiment 1, rats consumed one of the diets (n = 9/diet group) as the sole source of nutrition for 16 days. In Experiment 2, diets were offered as an option to nutritionally complete chow for 4 days followed by a 3-day chow-only washout in a randomized within-subjects design (n = 30). In Experiment 3, nine rats received isocaloric intragastric infusions of diet overnight, with chow available ad libitum. At least two no-infusion days separated the different diet infusions, which were given in random order. Food intake was measured daily Dietary fat dose dependently increased total daily kilocalories in each of the three paradigms. These data imply that the postingestive effects of carbohydrate and fat differentially engage the physiological substrates that regulate daily caloric intake. These findings reiterate the importance of investigating macronutrient-specific controls of feeding, rather than prematurely concluding that dietary attributes that covary with fat content (e.g., caloric density and palatability) drive the overeating associated with a high-fat diet.Keywords
This publication has 23 references indexed in Scilit:
- Dietary fat content affects energy intake and weight gain independent of diet caloric density in ratsPhysiology & Behavior, 2002
- High-fat diet feeding reduces the diurnal variation of plasma leptin concentration in ratsMetabolism, 2000
- Dietary Fat Intake and Regulation of Energy Balance: Implications for ObesityJournal of Nutrition, 2000
- Behavioral components of high-fat diet hyperphagia: meal size and postprandial satiety.American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2000
- Energy density but not fat content of foods affected energy intake in lean and obese womenThe American Journal of Clinical Nutrition, 1999
- Probing the causes of high-fat diet hyperphagia: A mechanistic and behavioral dissectionNeuroscience & Biobehavioral Reviews, 1996
- Energy Density and its Role in the Control of Food Intake: Evidence from Metabolic and Community StudiesAppetite, 1996
- Role of dietary fat in calorie intake and weight gainNeuroscience & Biobehavioral Reviews, 1992
- The satiety effects of intragastric macronutrient infusions in fatty and lean Zucker rats☆☆☆Physiology & Behavior, 1983
- Effects of equicaloric loads of protein, fat, and carbohydrate on food intake in the rat and manPhysiology & Behavior, 1979