The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity
Open Access
- 27 November 2014
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cellular Neuroscience
- Vol. 8, 401
- https://doi.org/10.3389/fncel.2014.00401
Abstract
In the mammalian central nervous system, excitatory glutamatergic synapses harness neurotransmission that is mediated by ion flow through AMPA receptors. AMPARs, which are enriched in the post-synaptic membrane on dendritic spines, are highly dynamic, and shuttle in and out of synapses in an activity-dependent manner. Changes in their number, subunit composition, phosphorylation state, and accessory proteins can all regulate AMPARs and thus modify synaptic strength and support cellular forms of learning. Furthermore, dysregulation of AMPAR plasticity has been implicated in various pathological states and has important consequences for mental health. Here we focus on the mechanisms that control AMPAR plasticity, drawing particularly from the extensive studies on hippocampal synapses, and highlight recent advances in the field along with considerations for future directions.Keywords
This publication has 141 references indexed in Scilit:
- Homeostatic synaptic plasticity: from single synapses to neural circuitsCurrent Opinion in Neurobiology, 2012
- Glutamate receptor subunit GluA1 is necessary for long-term potentiation and synapse unsilencing, but not long-term depression in mouse hippocampusBrain Research, 2012
- Syntaxin-4 Defines a Domain for Activity-Dependent Exocytosis in Dendritic SpinesCell, 2010
- Mixed Microtubules Steer Dynein-Driven Cargo Transport into DendritesCurrent Biology, 2010
- Network homeostasis: a matter of coordinationCurrent Opinion in Neurobiology, 2009
- Myosin Vb Mobilizes Recycling Endosomes and AMPA Receptors for Postsynaptic PlasticityCell, 2008
- Identification and characterization of a novel phosphorylation site on the GluR1 subunit of AMPA receptorsMolecular and Cellular Neuroscience, 2007
- The EJC Factor eIF4AIII Modulates Synaptic Strength and Neuronal Protein ExpressionCell, 2007
- Diffusional Trapping of GluR1 AMPA Receptors by Input-Specific Synaptic ActivityNeuron, 2007
- Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA ReceptorsNeuron, 2006