The changing epidemiology of thyroid cancer
Top Cited Papers
- 1 January 2015
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Current Opinion in Oncology
- Vol. 27 (1), 1-7
- https://doi.org/10.1097/cco.0000000000000148
Abstract
Thyroid cancer incidence is increasing worldwide. Causes are highly debated.Thyroid cancer increase has been associated to socioeconomic status, better access to healthcare and rising use of thyroid imaging. Therefore, the rise could be apparent because of the useless identification of a large reservoir of subclinical papillary lesions that will never affect patient health (overdiagnosis).However, not all epidemiological and clinical data support this hypothesis. The increasing number of large tumors, the increasing thyroid cancer-related mortality in spite of earlier treatment and the changes in thyroid cancer molecular profile suggest a true increase. Recently increased and thyroid-specific environmental carcinogens could be responsible, such as radiation (mostly medical radiation), increased iodine intake and chronic lymphocytic thyroiditis and environmental pollutants such as nitrates, heavy metals and other compounds largely used in the industrialized society. Possible mechanisms await further investigation.The increased incidence of thyroid cancer is the likely result of two coexisting processes: increased detection (apparent increase) and increased number of cases (true increase) due to unrecognized thyroid-specific carcinogens.To identify causal factors and to differentiate stationary cancers from those that will progress are major urgent requirements for both clinical and scientific purposes.Keywords
This publication has 23 references indexed in Scilit:
- Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United StatesCancer Research, 2014
- Current Thyroid Cancer Trends in the United StatesJAMA Otolaryngology–Head & Neck Surgery, 2014
- Incidence of Differentiated Thyroid Cancer by Socioeconomic Status and Urban Residence: Canada 1991–2006Thyroid®, 2014
- The Increase in Thyroid Cancer Incidence During the Last Four Decades Is Accompanied by a High Frequency ofBRAFMutations and a Sharp Increase inRASMutationsJournal of Clinical Endocrinology & Metabolism, 2014
- Thyroid Cancers Detected by Imaging Are Not Necessarily Small or Early StageThyroid®, 2014
- Regional Variation in Thyroid Cancer Incidence in Belgium Is Associated With Variation in Thyroid Imaging and Thyroid Disease ManagementJournal of Clinical Endocrinology & Metabolism, 2013
- The Increasing Incidence of Thyroid Cancer: The Influence of Access to CareThyroid®, 2013
- Increasing incidence of thyroid cancer: controversies exploredNature Reviews Endocrinology, 2013
- The Prevalence of Occult Medullary Thyroid Carcinoma at AutopsyJournal of Clinical Endocrinology & Metabolism, 2011
- Occult thyroid pathology in the young adult: An autopsy study of 138 patients without clinical thyroid diseaseHuman Pathology, 1988