Comparative Epidemiology of Human Infections with Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome Coronaviruses among Healthcare Personnel
Open Access
- 1 March 2016
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 11 (3), e0149988
- https://doi.org/10.1371/journal.pone.0149988
Abstract
The largest nosocomial outbreak of Middle East respiratory syndrome (MERS) occurred in South Korea in 2015. Health Care Personnel (HCP) are at high risk of acquiring MERS-Coronavirus (MERS-CoV) infections, similar to the severe acute respiratory syndrome (SARS)-Coronavirus (SARS-CoV) infections first identified in 2003. This study described the similarities and differences in epidemiological and clinical characteristics of 183 confirmed global MERS cases and 98 SARS cases in Taiwan associated with HCP. The epidemiological findings showed that the mean age of MERS-HCP and total MERS cases were 40 (24~74) and 49 (2~90) years, respectively, much older than those in SARS [SARS-HCP: 35 (21~68) years, p = 0.006; total SARS: 42 (0~94) years, p = 0.0002]. The case fatality rates (CFR) was much lower in MERS-HCP [7.03% (9/128)] or SARS-HCP [12.24% (12/98)] than the MERS-non-HCP [36.96% (34/92), p.001] or SARS-non-HCP [24.50% (61/249), p.001], however, no difference was found between MERS-HCP and SARS-HCP [p = 0.181]. In terms of clinical period, the days from onset to death [13 (4~17) vs 14.5 (0~52), p = 0.045] and to discharge [11 (5~24) vs 24 (0~74), p = 0.010] and be hospitalized days [9.5 (3~22) vs 22 (0~69), p = 0.040] were much shorter in MERS-HCP than SARS-HCP. Similarly, days from onset to confirmation were shorter in MERS-HCP than MERS-non-HCP [6 (1~14) vs 10 (1~21), p = 0.044]. In conclusion, the severity of MERS-HCP and SARS-HCP was lower than that of MERS-non-HCP and SARS-non-HCP due to younger age and early confirmation in HCP groups. However, no statistical difference was found in MERS-HCP and SARS-HCP. Thus, prevention of nosocomial infections involving both novel Coronavirus is crucially important to protect HCP.This publication has 29 references indexed in Scilit:
- Middle East Respiratory Syndrome Coronavirus in Bats, Saudi ArabiaEmerging Infectious Diseases, 2013
- Middle East Respiratory Syndrome Coronavirus Infections in Health Care WorkersThe New England Journal of Medicine, 2013
- Progress in Global Surveillance and Response Capacity 10 Years after Severe Acute Respiratory SyndromeEmerging Infectious Diseases, 2013
- Establishing a nationwide emergency department-based syndromic surveillance system for better public health responses in TaiwanBMC Public Health, 2008
- Transmission of SARS to healthcare workers. The experience of a Hong Kong ICUIntensive Care Medicine, 2006
- Seroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groupsEpidemiology and Infection, 2005
- Seroprevalence of Antibody to Severe Acute Respiratory Syndrome (SARS)-Associated Coronavirus among Health Care Workers in SARS and Non-SARS Medical WardsClinical Infectious Diseases, 2004
- Superspreading SARS Events, Beijing, 2003Emerging Infectious Diseases, 2004
- Early detection of antibodies against various structural proteins of the SARS-associated coronavirus in SARS patientsJournal of Biomedical Science, 2004
- WHO warns that death rate from SARS could reach 10%BMJ, 2003