Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis
Open Access
- 17 August 2007
- journal article
- other
- Published by BMJ in Annals Of The Rheumatic Diseases
- Vol. 67 (5), 677-682
- https://doi.org/10.1136/ard.2007.071399
Abstract
Objective: Psoriasis of early onset (type I; age of onset ⩽40 years) is associated with HLA-Cw*06 while the shared epitope (SE) is associated with rheumatoid arthritis susceptibility. Our aim was to investigate the role of HLA-Cw*06 and HLA-DRB1 genes (including SE) with psoriatic arthritis (PsA) susceptibility. Methods: In a case–control association study, HLA-Cw*06 phenotype frequencies were compared between patients with PsA (n = 480), psoriasis alone (n = 611) and healthy controls (n = 166). Similarly, at the HLA-DRB1 locus, phenotype and SE frequencies were compared in patients with PsA (n = 480), early undifferentiated inflammatory arthritis alone (n = 1621) and healthy controls (n = 537). Results: The HLA-Cw*06 phenotype was associated with type I psoriasis (OR 6.9, 95% CI 4.4, 11.1, p = 2.2×10−21) and with patients with PsA having type I psoriasis (OR 5.0, 95% CI 3.2, 7.9, p = 4.39×10−13), but not with patients with PsA having type II psoriasis (age of onset >40 years). HLA-DRB1*07, in linkage disequilibrium with HLA-Cw*06, was also associated with patients with PsA having type I psoriasis (OR 2.7, 95% CI 2.1, 3.7, pHLA-DRB1*04 alleles and the SE were associated with undifferentiated inflammatory arthritis but not with PsA. Conclusions: The SE is not a PsA susceptibility locus. HLA-Cw*06 and HLA-DRB1*07 are associated with patients with PsA having type I psoriasis, suggesting that the primary association is with age of onset of psoriasis. Patients with PsA having type I psoriasis, therefore, have a genetic background different to those with type II psoriasis, and adjustment for this is necessary in future studies that investigate the genetic susceptibility of PsA.This publication has 45 references indexed in Scilit:
- HLA-Cw6 and HLA-DRB1*07 together are associated with less severe joint disease in psoriatic arthritisAnnals Of The Rheumatic Diseases, 2007
- Polyarticular psoriatic arthritis is more like oligoarticular psoriatic arthritis, than rheumatoid arthritisAnnals Of The Rheumatic Diseases, 2006
- HLA is a candidate region for psoriatic arthritis: evidence for excessive HLA sharing in sibling pairsHuman Immunology, 2003
- Polymorphism in MICA rather than HLA-B/C genes is associated with psoriatic arthritis in the Jewish populationHuman Immunology, 2001
- ANNOUNCEMENTS AND CALENDAR FOR 1991–92Rheumatology, 1991
- HLA antigens in psoriatic arthritis subtypes of a Spanish population.Annals Of The Rheumatic Diseases, 1990
- The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisArthritis & Rheumatism, 1988
- Psoriatic arthritis: clinical subgroups and histocompatibility antigens.Annals Of The Rheumatic Diseases, 1987
- HLA antigens in psoriasis and psoriatic arthritis.Journal of Medical Genetics, 1985
- Psoriasis and HLA-Cw6British Journal of Dermatology, 1980