Risk of differentiated thyroid cancer in relation to adult weight, height and body shape over life: The French E3N cohort
- 9 April 2010
- journal article
- Published by Wiley in International Journal of Cancer
- Vol. 126 (12), 2984-2990
- https://doi.org/10.1002/ijc.25066
Abstract
The increasing incidence rate of thyroid cancer warrants investigation of potentially modifiable factors, especially overweightness. Few prospective studies have investigated anthropometry from childhood to adulthood in relation to thyroid cancer. We analyzed data from 91,909 women of the E3N study, a cohort of French women insured by a national health scheme mostly covering teachers with the age of 40–65 years at inclusion in 1990. Risk estimates of first primary differentiated thyroid cancer (n = 317) were computed using Cox proportional hazards models. There was a significant dose–effect relationship between thyroid cancer risk and weight or body mass index (BMI) but not height. Compared with women whose BMI was 18.5–22 kg/m2, women with BMI 22–25 and those with BMI over 30 had a 39% [95% confidence interval (CI) 7–81] and 76% (12–176) higher risk of thyroid cancer, respectively, with a 21% (5–39) increased risk per 5 kg/m2 increase in BMI. A large body shape from age 35–40 was significantly associated with an increased risk of differentiated thyroid cancer when compared with a lean one, while earlier body shapes were not. The highest risk was observed in women whose body shape increased from lean to large between menarche and adulthood, with a HR of 2.17 (95% CI 1.04–4.53) when compared with women who were lean at both periods. Our study adds to the existing evidence in relation to excess weight to the risk of thyroid cancer, particularly in women whose body shape increased from menarche to adult age.Keywords
This publication has 17 references indexed in Scilit:
- Anthropometric factors in differentiated thyroid cancer in French Polynesia: a case–control studyCancer Causes & Control, 2008
- International patterns and trends in thyroid cancer incidence, 1973–2002Cancer Causes & Control, 2008
- Anthropometric factors at age 20 years and risk of thyroid cancerCancer Causes & Control, 2008
- Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studiesThe Lancet, 2008
- Alcohol Drinking, Tobacco Smoking, and Anthropometric Characteristics as Risk Factors for Thyroid Cancer: A Countrywide Case-Control Study in New CaledoniaAmerican Journal of Epidemiology, 2007
- Body size and thyroid cancer in two million Norwegian men and womenBritish Journal of Cancer, 2006
- Body silhouette, menstrual function at adolescence and breast cancer risk in the E3N cohort studyBritish Journal of Cancer, 2005
- The EPIC Project: rationale and study design. European Prospective Investigation into Cancer and NutritionInternational Journal of Epidemiology, 1997
- A case-control study of thyroid cancer in women under age 55 in Shanghai (People's Republic of China)Cancer Causes & Control, 1993
- The association of body size, reproductive factors and thyroid cancerBritish Journal of Cancer, 1992