Lest we forget the endothelial glycocalyx in sepsis
Open Access
- 1 January 2012
- journal article
- review article
- Published by Springer Science and Business Media LLC in Critical Care
- Vol. 16 (2), 121
- https://doi.org/10.1186/cc11239
Abstract
Sepsis is the third largest cause of death in industrialised countries, but treatment remains largely supportive and effective therapeutic interventions are urgently needed. Disruption and dysfunction of the microvascular endothelium leading directly or indirectly to multiple organ failure are now recognised to underpin the pathophysiology of sepsis. Biomarkers of endothelial activation may therefore assume an important role in guiding future research efforts. We suggest that integral to this approach is the investigation and evaluation of endothelial glycocalyx biomarkers, not only as indicators of the pathogenic process but also to inform the development of pharmacological and other therapies.Keywords
This publication has 15 references indexed in Scilit:
- Clinical utility of biomarkers of endothelial activation in sepsis-a systematic reviewCritical Care, 2012
- Syndecans as cell surface receptors: Unique structure equates with functional diversityMatrix Biology, 2011
- Biomarkers of endothelial dysfunction: can they help us deciphering systemic inflammation and sepsis?Biomarkers, 2011
- Sepsis and Major Abdominal Surgery Lead to Flaking of the Endothelial GlycocalixJournal of Surgical Research, 2011
- Therapeutic strategies targeting the endothelial glycocalyx: acute deficits, but great potentialCardiovascular Research, 2010
- Sepsis biomarkers: a reviewCritical Care, 2010
- The impact of the glycocalyx on microcirculatory oxygen distribution in critical illnessCurrent Opinion in Anaesthesiology, 2009
- Endothelial glycocalyx as potential diagnostic and therapeutic target in cardiovascular diseaseCurrent Opinion in Lipidology, 2009
- INCREASED LEVELS OF GLYCOSAMINOGLYCANS DURING SEPTIC SHOCKShock, 2008
- Endothelial Glycocalyx: Sweet Shield of Blood VesselsTrends in Cardiovascular Medicine, 2007