Successful Treatment by Surgery and Lenvatinib of a Patient with Adrenal Metastasis of Papillary Thyroid Cancer
Open Access
- 5 November 2020
- journal article
- research article
- Published by Hindawi Limited in Case Reports in Oncological Medicine
- Vol. 2020, 1-4
- https://doi.org/10.1155/2020/2107430
Abstract
Papillary thyroid cancer (PTC) is considered an indolent cancer, but some PTC patients do present with distant metastases and treatment strategies for such patients are not well established. Recently, lenvatinib, an inhibitor of multiple tyrosine kinases, has been introduced to treat patients with advanced PTC but carries a risk of serious adverse events such as hemorrhage. Here, we report a PTC patient with a left adrenal metastasis and lenvatinib-induced hemorrhage who underwent successful surgical resection and was subsequently treated with a lower dose of lenvatinib. The patient has now been in a stable state with no adverse events for nearly two years. This case highlights the importance of surgical resection of metastatic PTC and subsequent lenvatinib therapy, even when the tumor is at an advanced stage.Keywords
This publication has 11 references indexed in Scilit:
- Managing the adverse events associated with lenvatinib therapy in radioiodine-refractory differentiated thyroid cancerSeminars in Oncology, 2019
- Lenvatinib versus Placebo in Radioiodine-Refractory Thyroid CancerThe New England Journal of Medicine, 2015
- Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trialThe Lancet, 2014
- Papillary Thyroid Cancer with Bilateral Adrenal MetastasesThyroid®, 2013
- Optimizing therapy for radioactive iodine-refractory differentiated thyroid cancer: current state of the art and future directions.2012
- Vandetanib in Patients With Locally Advanced or Metastatic Medullary Thyroid Cancer: A Randomized, Double-Blind Phase III TrialJournal of Clinical Oncology, 2012
- Prognosis and prognostic factors of patients with papillary carcinoma showing distant metastasis at surgery (M1 patients) in JapanEndocrine Journal, 2010
- Clinical management and outcome of papillary and follicular (differentiated) thyroid cancer presenting with distant metastasis at diagnosisCancer, 2007
- Long-Term Outcome of 444 Patients with Distant Metastases from Papillary and Follicular Thyroid Carcinoma: Benefits and Limits of Radioiodine TherapyJournal of Clinical Endocrinology & Metabolism, 2006
- Long-term survivor without recurrence after resection of simultaneous solitary pancreatic metastasis from thyroid medullary carcinoma.2003