Protective Signaling by Activated Protein C Is Mechanistically Linked to Protein C Activation on Endothelial Cells
Open Access
- 1 July 2006
- journal article
- Published by Elsevier BV
- Vol. 281 (29), 20077-20084
- https://doi.org/10.1074/jbc.m600506200
Abstract
No abstract availableKeywords
This publication has 42 references indexed in Scilit:
- Protease-activated Receptor-1 Signaling by Activated Protein C in Cytokine-perturbed Endothelial Cells Is Distinct from Thrombin SignalingPublished by Elsevier BV ,2005
- Patients with severe sepsis vary markedly in their ability to generate activated protein CBlood, 2004
- Activated Protein C Induces Endothelial Cell Proliferation by Mitogen-Activated Protein Kinase Activation In Vitro and Angiogenesis In VivoCirculation Research, 2004
- Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotectiveNature Medicine, 2003
- The Thrombin Mutant W215A/E217A Shows Safe and Potent Anticoagulant and Antithrombotic Effects in VivoJournal of Biological Chemistry, 2002
- Dysfunction of Endothelial Protein C Activation in Severe Meningococcal SepsisNew England Journal of Medicine, 2001
- Identification of the Protein C/Activated Protein C Binding Sites on the Endothelial Cell Protein C ReceptorJournal of Biological Chemistry, 2001
- Gating of thrombin in platelet aggregates by pO2-linked lowering of extracellular Ca2+ concentrationBiochemistry, 1995
- Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates.JCI Insight, 1993
- Deficiency of protein C in congenital thrombotic disease.JCI Insight, 1981