Predictors of carotid stent restenosis
- 9 March 2007
- journal article
- research article
- Published by Wiley in Catheterization and Cardiovascular Interventions
- Vol. 69 (5), 673-682
- https://doi.org/10.1002/ccd.20809
Abstract
Objectives: We sought to determine the predictors of restenosis after carotid artery stenting and report alternatives for its management. Background: Carotid artery stenting has been increasingly accepted as an alternative to carotid endarterectomy (CEA). Predictors of carotid stent restenosis have not been firmly established, and management of restenotic lesions can be challenging. Methods: A retrospective, single-center review was conducted of 399 carotid stent procedures in 363 patients over 9 years, with a mean follow-up of 24 months (range 6–99 months). Clinical variables included age, gender, symptoms, hypertension, diabetes, tobacco use, renal insufficiency, coronary artery disease, hyperlipidemia, peripheral vascular disease, history of CEA, and history of neck radiation (XRT). Angiographic variables included reference vessel diameter, lesion length, poststenting residual stenosis, stent diameter, type of stent, and number of stents. Results: Overall, restenosis occurred in 15 patients (3.8%). However, the restenosis occurred in 7 of 35 (20%) patients who had previous XRT, 6 of 57 (10.5%) patients who had previous CEA, and 2 of 9 (22%) patients who previously had both CEA and XRT. The only analyzed variables that were significantly associated with an increased risk of restenosis were previous CEA (OR 4.28, P = 0.008) or XRT (OR 11.3, P ≤≤ 0.0001). Restenosis was most often asymptomatic and detected at routine ultrasound follow-up. Restenotic lesions were successfully treated in 11/11 cases with angioplasty (27%) or stenting (73%). Four patients that are asymptomatic are being monitored closely with ultrasound. No patients required surgical therapy for restenosis. Conclusions: Restenosis after carotid stenting is uncommon; however, patients with previous CEA or XRT are at increased risk. Restenotic lesions may be safely treated with further percutaneous interventions.Keywords
This publication has 39 references indexed in Scilit:
- Surveillance imaging for carotid in‐stent restenosisCatheterization and Cardiovascular Interventions, 2006
- Determining In-Stent Stenosis of Carotid Arteries by Duplex Ultrasound CriteriaJournal of Endovascular Therapy, 2005
- Restenosis After Carotid Angioplasty, Stenting, or Endarterectomy in the Carotid and Vertebral Artery Transluminal Angioplasty Study (CAVATAS)Stroke, 2005
- Carotid artery stenting: is there a need to revise ultrasound velocity criteria?Journal of Vascular Surgery, 2004
- Predictors of restenosis after successfulcarotid artery stentingThe American Journal of Cardiology, 2003
- Carotid artery stenting: analysis of data for 105 patients at high riskJournal of Vascular Surgery, 2003
- Follow-up of Stented Carotid Arteries by Doppler UltrasoundNeurosurgery, 2002
- Safety, Efficacy, and Durability of Carotid Artery Stenting for Restenosis Following Carotid Endarterectomy: A Multicenter StudyJournal of Endovascular Therapy, 2000
- Carotid Recurrent Stenosis and Risk of Ipsilateral StrokeStroke, 1998
- Correlation of Peak Systolic Velocity and Angiographic Measurement of Carotid Stenosis RevisitedStroke, 1997