MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo
Open Access
- 26 September 2007
- journal article
- research article
- Published by Wiley in Magnetic Resonance in Medicine
- Vol. 58 (4), 650-655
- https://doi.org/10.1002/mrm.21393
Abstract
In this report, the On resonance PARamagnetic CHemical Exchange Effects (OPARACHEE) method was implemented in vivo using WALTZ-16* as a preparation pulse with a standard spin echo sequence to detect the accumulation and clearance of the TmDOTA-4AmC− in mouse kidney. The performance of the technique in vivo is described in terms of the magnitude of the contrast effect versus the bolus agent concentration and signal-to-noise ratio (SNR) levels. The lowest injected concentration of TmDOTA-4AmC−, 200 μL of a 2-mM stock solution (corresponds to ∼0.2 mM agent in plasma), reduced the total water signal in the kidney papilla by 45% 3 min after the a bolus injection. The results show that the OPARACHEE methodology employing low-amplitude RF trains can detect paramagnetic exchanging agents in vivo. Magn Reson Med 58:650–655, 2007.Keywords
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