Exploring the therapeutic space around NAD+
Open Access
- 15 October 2012
- journal article
- editorial
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 199 (2), 205-209
- https://doi.org/10.1083/jcb.201207019
Abstract
NAD(+) is a central metabolite in the cell. Changes in NAD(+) abundance and the activity of NAD(+)-dependent enzymes, such as the sirtuins, are at the core of metabolic/mitochondrial diseases, such as obesity and diabetes, and of cancer and neurodegeneration. Here, we discuss how maintaining or raising NAD(+) levels can improve metabolism and prevent age-related functional decline and associated disease, and how basic scientific discoveries in the NAD(+) signaling pathway are being translated to the clinic.Keywords
This publication has 45 references indexed in Scilit:
- Absence of effects of Sir2 overexpression on lifespan in C. elegans and DrosophilaNature, 2011
- PARP-2 Regulates SIRT1 Expression and Whole-Body Energy ExpenditureCell Metabolism, 2011
- PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 ActivationCell Metabolism, 2011
- Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegansMechanisms of Ageing and Development, 2007
- The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet‐induced obesityThe FASEB Journal, 2007
- Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triageProceedings of the National Academy of Sciences of the United States of America, 2006
- Resveratrol improves health and survival of mice on a high-calorie dietNature, 2006
- Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and HumansCell, 2004
- The new life of a centenarian: signalling functions of NAD(P)Trends in Biochemical Sciences, 2004
- Influence of nicotinic acid on serum cholesterol in manArchives of Biochemistry and Biophysics, 1955