Highly pathogenic avian influenza outbreak mitigated by seasonal low pathogenic strains: Insights from dynamic modeling
- 21 February 2011
- journal article
- Published by Elsevier BV in Journal of Theoretical Biology
- Vol. 271 (1), 181-201
- https://doi.org/10.1016/j.jtbi.2010.11.013
Abstract
The spread of highly pathogenic avian influenza (HPAI) H5N1 remains a threat for both wild and domestic bird populations, while low pathogenic avian influenza (LPAI) strains have been reported to induce partial immunity to HPAI in poultry and some wild birds inoculated with both HPAI and LPAI strains. Here, based on the reported data and experiments, we develop a two-strain avian influenza model to examine the extent to which this partial immunity observed at the individual level can affect the outcome of the outbreaks among migratory birds in the wild at the population level during different seasons. We find a distinct mitigating effect of LPAI on the death toll induced by HPAI strain, and this effect is particularly important for populations previously exposed to and recovered from LPAI. We further investigate the effect of the dominant mode of transmission of an HPAI strain on the outcome of the epidemic. Four combinations of contact based direct transmission and indirect fecal-to-oral (or environmental) routes are examined. For a given infection peak of HPAI, indirect fecal-to-oral transmission of HPAI can lead to a higher death toll than that associated with direct transmission. The mitigating effect of LPAI can, in turn, be dependent on the route of infection of HPAI.Keywords
This publication has 24 references indexed in Scilit:
- Spatial dynamics of bar-headed geese migration in the context of H5N1Journal of The Royal Society Interface, 2010
- The construction of next-generation matrices for compartmental epidemic modelsJournal of The Royal Society Interface, 2009
- Environmental transmission of low pathogenicity avian influenza viruses and its implications for pathogen invasionProceedings of the National Academy of Sciences, 2009
- The Role of Environmental Transmission in Recurrent Avian Influenza EpidemicsPLoS Computational Biology, 2009
- Wild Ducks as Long-Distance Vectors of Highly Pathogenic Avian Influenza Virus (H5N1)Emerging Infectious Diseases, 2008
- Mapping H5N1 highly pathogenic avian influenza risk in Southeast AsiaProceedings of the National Academy of Sciences of the United States of America, 2008
- Experimental Infection of Swans and Geese with Highly Pathogenic Avian Influenza Virus (H5N1) of Asian LineageEmerging Infectious Diseases, 2008
- Susceptibility of Canada Geese (Branta canadensis) to Highly Pathogenic Avian Influenza Virus (H5N1)Emerging Infectious Diseases, 2007
- Characterization of Low-Pathogenicity H5N1 Avian Influenza Viruses from North AmericaJournal of Virology, 2007
- Perspectives on the basic reproductive ratioJournal of The Royal Society Interface, 2005