The tumor suppressor role of CTCF
- 4 April 2011
- journal article
- review article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 227 (2), 479-492
- https://doi.org/10.1002/jcp.22780
Abstract
CTCF is an evolutionary conserved and ubiquitously expressed protein that binds thousands of sites in the human genome. Ectopic expression of CTCF in various normal and tumoral human cell lines inhibits cell division and clonogenicity, with the consequence to consider CTCF a potential tumor‐suppressor factor. In this review article, we focused on the molecular mechanisms engaged by CTCF to modulate the expression of several key‐regulators of differentiation, cellular senescence, cell cycle control and progression, whose expression is frequently altered in tumors. Moreover, we discussed common features of CTCF at each tumor‐related DNA‐binding sequence, such as protein‐partners, post‐translational modifications, and distinctive epigenetic marks establishment. The investigation of the molecular mechanisms engaged by CTCF to modulate tumor‐related genes emphasizes the cell‐type dependency of its tumor suppressor role. Indeed, the ability of CTCF to bind their promoters strictly depends by cell‐type features as DNA methylation, BORIS‐binding and post‐translational modifications as PARYlation. J. Cell. Physiol. 227: 479–492, 2012.Keywords
This publication has 160 references indexed in Scilit:
- Functional Analysis of CTCF During Mammalian Limb DevelopmentDevelopmental Cell, 2010
- Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular SenescenceCancer Cell, 2010
- CTCF: Master Weaver of the GenomeCell, 2009
- Epigenetic Silencing of the p16 Tumor Suppressor Is Associated with Loss of CTCF Binding and a Chromatin BoundaryMolecular Cell, 2009
- The LPS-Induced Transcriptional Upregulation of the Chicken Lysozyme Locus Involves CTCF Eviction and Noncoding RNA TranscriptionMolecular Cell, 2008
- High-Resolution Profiling of Histone Methylations in the Human GenomeCell, 2007
- Analysis of the Vertebrate Insulator Protein CTCF-Binding Sites in the Human GenomeCell, 2007
- Connections between epigenetic gene silencing and human diseaseMutation Research, 2007
- CpG islands: features and distribution in the genomes of vertebratesGene, 1991
- CpG Islands in vertebrate genomesJournal of Molecular Biology, 1987