Is prostate-specific membrane antigen a multifunctional protein?
- 1 May 2005
- journal article
- review article
- Published by American Physiological Society in American Journal of Physiology-Cell Physiology
- Vol. 288 (5), C975-C981
- https://doi.org/10.1152/ajpcell.00506.2004
Abstract
Prostate-specific membrane antigen (PSMA) is a metallopeptidase expressed predominantly in prostate cancer (PCa) cells. PSMA is considered a biomarker for PCa and is under intense investigation for use as an imaging and therapeutic target. Although the clinical utility of PSMA in the detection and treatment of PCa is evident and is being pursued, very little is known about its basic biological function in PCa cells. The purpose of this review is to highlight the possibility that PSMA might be a multifunctional protein. We suggest that PSMA may function as a receptor internalizing a putative ligand, an enzyme playing a role in nutrient uptake, and a peptidase involved in signal transduction in prostate epithelial cells. Insights into the possible functions of PSMA should improve the diagnostic and therapeutic values of this clinically important molecule.Keywords
This publication has 51 references indexed in Scilit:
- Transferrin receptor 1The International Journal of Biochemistry & Cell Biology, 2004
- Stromal–epithelial interactions influence prostate cancer cell invasion by altering the balance of metallopeptidase expressionBritish Journal of Cancer, 2004
- Targeting Metastatic Prostate Cancer With Radiolabeled Monoclonal Antibody J591 to the Extracellular Domain of Prostate Specific Membrane AntigenJournal of Urology, 2003
- Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N‐acetylaspartylglutamateJournal of Neurochemistry, 2002
- Expression analysis of δ‐catenin and prostate‐specific membrane antigen: Their potential as diagnostic markers for prostate cancerInternational Journal of Cancer, 2002
- Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migrationNature, 2001
- Comparison of anti-prostate-specific membrane antigen antibodies and other immunomarkers in metastatic prostate carcinomaUrology, 2001
- Cloning, expression, genomic localization, and enzymatic activities of the mouse homolog of prostate-specific membrane antigen/NAALADase/folate hydrolaseMammalian Genome, 2001
- Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase.Proceedings of the National Academy of Sciences of the United States of America, 1996
- Functional role of CD26 on human B lymphocytesImmunology Letters, 1995