Genetic heterogeneity and localization of a familial breast-ovarian cancer gene on chromosome 17q12-q21.
- 1 April 1993
- journal article
- Vol. 52 (4), 767-76
Abstract
In a study of 31 breast cancer families and 12 breast-ovarian cancer families, we have obtained clear evidence of linkage to markers on chromosome 17q in the families with ovarian cancer (maximum lod score 3.34 at theta = .04) but only weak evidence in those without ovarian cancer. Recombinant events indicate that the gene lies between D17S588 and D17S250.This publication has 6 references indexed in Scilit:
- Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.1993
- Closing in on a breast cancer gene on chromosome 17q.1992
- Familial breast-ovarian cancer locus on chromosome 17q12-q23The Lancet, 1991
- Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21Science, 1990
- Dinucleotide repeat polymorphisms at the D17S250 and D17S261 lociNucleic Acids Research, 1990
- A mapped set of DNA markers for human chromosome 17Genomics, 1988