Efficient Synthesis of Solasodine, O‐Acetylsolasodine, and Soladulcidine as Anticancer Steroidal Alkaloids
- 26 January 2007
- journal article
- research article
- Published by Wiley in Chemistry & Biodiversity
- Vol. 4 (1), 25-31
- https://doi.org/10.1002/cbdv.200790003
Abstract
An efficient synthesis of the steroidal alkaloids solasodine (1), O-acetylsolasodine (2), and soladulcidine (3) starting from easily available diosgenin and tigogenin in five or six steps (overall yield 25, 24, and 28%, resp.) is described. Moreover, our synthetic route provides a selective modification at C(3) of 1 and related compounds in order to carry out lead optimization on these natural antitumor steroidal alkaloids.Keywords
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